KIT Center MathSEE

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Tuesday, 23 October 2018
18:00 
KIT-Zentrum MathSEE Gründungsempfang / KIT Center MathSEE Reception
Jubiläumsfeier
KIT, Campus Süd
Geb. 20.30 …

Das KIT-Zentrum „MathSEE“ (Mathematik in den Natur-, Ingenieur- und Wirtschaftswissenschaften – Mathematics (Math) in Sciences, Engineering and Economics (SEE)) startet offiziell zum 1. Oktober 2018 seine Arbeit.
Wir feiern die Eröffnung mit einem Empfang, zu dem alle KIT-Angehörigen herzlich eingeladen sind.
Um Anmeldung unter tanja.hagedorn@kit.edu wird gebeten.
 
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The KIT Center MathSEE (Mathematics (Math) in Sciences, Engineering and Economics (SEE)) officially starts working on October 1st, 2018.
All KIT members are cordially invited to the reception in honor of the establishment.
Registration is kindly requested via email to tanja.hagedorn@kit.edu.

Monday, 12 November 2018
Monday, 10 December 2018
15:00 - 16:00 
Mathematical models of adhesion assembly and disassembly in cell motility
Seminar
Campus North, Building 316 (ITG), seminar room
Prof. Anmar Khadra, McGill University, Dept. Physiology

Cellular migration is crucial in both physiological and pathological functions. Maintenance of proper migration and development of aberrant migration are effectuated by cellular machinery involving protein complexes, called adhesions, that anchor the cell to its environment. Over time, these adhesions assemble at the leading edge, as the cell extends forward, anchoring the front of the cells to its substrate, while those at the cell rear disassemble, allowing detachment and forward movement. Their dynamics are controlled by a number of regulatory factors, occurring on both cell-wide and adhesion-level scales. The coordination of these regulatory factors is complex, but insights about their dynamics can be gained from the use of mathematical/biophysical modeling techniques which integrate many of these components together. In this talk, I will present our recently developed models of cell polarity and adhesion dynamics to explore how local regulation of key adhesion proteins (including paxillin and integrin) produce cell-wide polarization associated with motility and directionality. The dynamics associated with various parameter regimes will be presented and insights into the mechanisms regulating assembly and disassembly of adhesions will be provided.​

Wednesday, 23 January 2019
Friday, 25 January 2019
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